Sciweavers

CDC
2008
IEEE

Modeling and control of the protein synthesis process in eukaryotic cells

13 years 10 months ago
Modeling and control of the protein synthesis process in eukaryotic cells
— Protein synthesis is an essential process of cell cycle and growth in eukaryotic cells. The initiation stage of the translation process is known to be the most crucial in regulation of gene expression. This paper presents a reduced model of the initiation process using the eukaryotic initiation factor (eIF)-2 unit and proposes methods to control it. Linearization of the model is presented as a measure to simplify the analysis and the control applications. The properties of the linear model were investigated and compared to the nonlinear model. It was shown that the linear model is (marginally) stable and a linear controller was introduced to regulate the production level of protein. A nonlinear state feedback control was also applied in order to increase production of protein in a controlled manner. In both linear and nonlinear models, the rate of protein synthesis can be regulated using a specific factor as an intracellular input, and by means of measurement techniques available ...
Nadav S. Bar, Rahmi Lale
Added 29 May 2010
Updated 29 May 2010
Type Conference
Year 2008
Where CDC
Authors Nadav S. Bar, Rahmi Lale
Comments (0)