Sciweavers

Share
ISBI
2011
IEEE

3D elastic registration improves HARDI-derived fiber alignment and automated tract clustering

10 years 9 months ago
3D elastic registration improves HARDI-derived fiber alignment and automated tract clustering
High angular resolution diffusion imaging (HARDI) allows population studies of fiber integrity and connectivity. Tractography can extract individual fibers. For group studies, fibers must be clustered into recognizable bundles found consistently across subjects. Nonlinear image registration may improve population clustering. To test this, we performed whole-brain tractography with an orientation distribution function based Hough transform method in 20 young adults scanned with 4 Tesla, 105-gradient HARDI. We warped all extracted fibers to a geometrically-centered template using a 3D elastic registration driven by fractional anisotropy maps, to align embedded tracts. Fiber alignment was evaluated by calculating distances among corresponding fibers across subjects. Before and after warping, we performed spectral clustering of the fibers using a k-means method, based on eigenvectors of a fiber similarity matrix. In tests with an overlap metric, non-rigid fiber warping yielded more robust...
Yan Jin, Yonggang Shi, Neda Jahanshad, Iman Aganj,
Added 21 Aug 2011
Updated 21 Aug 2011
Type Journal
Year 2011
Where ISBI
Authors Yan Jin, Yonggang Shi, Neda Jahanshad, Iman Aganj, Guillermo Sapiro, Arthur W. Toga, Paul M. Thompson
Comments (0)
books