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BMCBI
2011

An Agent-Based Model to study the epidemiological and evolutionary dynamics of Influenza viruses

10 years 5 months ago
An Agent-Based Model to study the epidemiological and evolutionary dynamics of Influenza viruses
Background: Influenza A viruses exhibit complex epidemiological patterns in a number of mammalian and avian hosts. Understanding transmission of these viruses necessitates taking into account their evolution, which represents a challenge for developing mathematical models. This is because the phrasing of multi-strain systems in terms of traditional compartmental ODE models either requires simplifying assumptions to be made that overlook important evolutionary processes, or leads to complex dynamical systems that are too cumbersome to analyse. Results: Here, we develop an Individual-Based Model (IBM) in order to address simultaneously the ecology, epidemiology and evolution of strain-polymorphic pathogens, using Influenza A viruses as an illustrative example. Conclusions: We carry out careful validation of our IBM against comparable mathematical models to demonstrate the robustness of our algorithm and the sound basis for this novel framework. We discuss how this new approach can give ...
Benjamin Roche, John M. Drake, Pejman Rohani
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2011
Where BMCBI
Authors Benjamin Roche, John M. Drake, Pejman Rohani
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