Analysis of Protein Protein Dimeric Interfaces

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Analysis of Protein Protein Dimeric Interfaces
We analyzed the structural properties and the local surface environment of surface amino acid residues of proteins using a large, non-redundant dataset of 2383 protein chains in dimeric complexes from PDB. We compared the interface residues and non-interface residues based on six properties: side chain orientation, surface roughness, solid angle, cx value, hydrophobicity and interface cluster size. The results of our analysis show that interface residues have side chains pointing inward; interfaces are rougher, tend to be flat, moderately convex or concave and protrude more relative to non-interface surface residues. Interface residues tend to be surrounded by hydrophobic neighbors and tend to form clusters consisting of three or more interfaces residues. These findings are consistent with previous published studies using much smaller datasets, while allowing for more qualitative conclusions due to our larger dataset. Preliminary results suggest the possibility of using the six the ...
Feihong Wu, Fadi Towfic, Drena Dobbs, Vasant Honav
Added 02 Jun 2010
Updated 02 Jun 2010
Type Conference
Year 2007
Where BIBM
Authors Feihong Wu, Fadi Towfic, Drena Dobbs, Vasant Honavar
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