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BMCBI
2011

Analysis on the reconstruction accuracy of the Fitch method for inferring ancestral states

8 years 2 months ago
Analysis on the reconstruction accuracy of the Fitch method for inferring ancestral states
Background: As one of the most widely used parsimony methods for ancestral reconstruction, the Fitch method minimizes the total number of hypothetical substitutions along all branches of a tree to explain the evolution of a character. Due to the extensive usage of this method, it has become a scientific endeavor in recent years to study the reconstruction accuracies of the Fitch method. However, most studies are restricted to 2-state evolutionary models and a study for higher-state models is needed since DNA sequences take the format of 4-state series and protein sequences even have 20 states. Results: In this paper, the ambiguous and unambiguous reconstruction accuracy of the Fitch method are studied for N-state evolutionary models. Given an arbitrary phylogenetic tree, a recurrence system is first presented to calculate iteratively the two accuracies. As complete binary tree and comb-shaped tree are the two extremal evolutionary tree topologies according to balance, we focus on the ...
Jialiang Yang, Jun Li, Liuhuan Dong, Stefan Gr&uum
Added 28 May 2011
Updated 28 May 2011
Type Journal
Year 2011
Where BMCBI
Authors Jialiang Yang, Jun Li, Liuhuan Dong, Stefan Grünewald
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