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SCALESPACE
2009
Springer

Bregman-EM-TV Methods with Application to Optical Nanoscopy

10 years 6 months ago
Bregman-EM-TV Methods with Application to Optical Nanoscopy
Abstract. Measurements in nanoscopic imaging suffer from blurring effects concerning different point spread functions (PSF). Some apparatus even have PSFs that are locally dependent on phase shifts. Additionally, raw data are affected by Poisson noise resulting from laser sampling and "photon counts" in fluorescence microscopy. In these applications standard reconstruction methods (EM, filtered backprojection) deliver unsatisfactory and noisy results. Starting from a statistical modeling in terms of a MAP likelihood estimation we combine the iterative EM algorithm with TV regularization techniques to make an efficient use of a-priori information. Typically, TV-based methods deliver reconstructed cartoon-images suffering from contrast reduction. We propose an extension to EM-TV, based on Bregman iterations and inverse scale space methods, in order to obtain improved imaging results by simultaneous contrast enhancement. We illustrate our techniques by synthetic and experi...
Christoph Brune, Alex Sawatzky, Martin Burger
Added 27 May 2010
Updated 27 May 2010
Type Conference
Year 2009
Where SCALESPACE
Authors Christoph Brune, Alex Sawatzky, Martin Burger
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