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2006

Circadian rhythm: A natural, robust, multi-scale control system

8 years 11 months ago
Circadian rhythm: A natural, robust, multi-scale control system
The regulatory architecture responsible for robust maintenance of 24 h cycles is analyzed as a control system. At the gene regulatory level, it is shown that performance attributes, notably phase timing, are controlled in a robust manner. At the next level in the hierarchy, it is shown that synchrony is achieved in populations of neurons to enable clock precision. Finally, at the level of the organism, it is shown that an optimal control approach can be used to reset the clock using a light stimulus.
Francis J. Doyle III, Rudiyanto Gunawan, Neda Bagh
Added 11 Dec 2010
Updated 11 Dec 2010
Type Journal
Year 2006
Where CCE
Authors Francis J. Doyle III, Rudiyanto Gunawan, Neda Bagheri, Henry Mirsky, Tsz Leung To
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