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BMCBI
2010

Circadian signatures in rat liver: from gene expression to pathways

9 years 4 months ago
Circadian signatures in rat liver: from gene expression to pathways
Background: Circadian rhythms are 24 hour oscillations in many behavioural, physiological, cellular and molecular processes that are controlled by an endogenous clock which is entrained to environmental factors including light, food and stress. Transcriptional analyses of circadian patterns demonstrate that genes showing circadian rhythms are part of a wide variety of biological pathways. Pathway activity method can identify the significant pattern of the gene expression levels within a pathway. In this method, the overall gene expression levels are translated to a reduced form, pathway activity levels, via singular value decomposition (SVD). A given pathway represented by pathway activity levels can then be as analyzed using the same approaches used for analyzing gene expression levels. We propose to use pathway activity method across time to identify underlying circadian pattern of pathways. Results: We used synthetic data to demonstrate that pathway activity analysis can evaluate t...
Meric A. Ovacik, Siddharth Sukumaran, Richard R. A
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2010
Where BMCBI
Authors Meric A. Ovacik, Siddharth Sukumaran, Richard R. Almon, Debra C. DuBois, William J. Jusko, Ioannis P. Androulakis
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