CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse

Background: Transcription Factors (TFs) and microRNAs (miRNAs) are key players for gene expression regulation in higher eukaryotes. In the last years, a large amount of bioinformatic studies were devoted to the elucidation of transcriptional and post-transcriptional (mostly miRNA-mediated) regulatory interactions, but little is known about the interplay between them. Description: Here we describe a dynamic web-accessible database, CircuitsDB, supporting a genome-wide transcriptional and post-transcriptional regulatory network integration, for the human and mouse genomes, based on a bioinformatic sequence-analysis approach. In particular, CircuitsDB is currently focused on the study of mixed miRNA/TF Feed-Forward regulatory Loops (FFLs), i.e. elementary circuits in which a master TF regulates an miRNA and together with it a set of Joint Target protein-coding genes. The database was constructed using an ab-initio oligo analysis procedure for the identification of the transcriptional and...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Olivier Friard, Angela Re, Daniela Taverna, Michele De Bortoli, Davide Corà
• Keywords: BMCBI 2010, Gene Expression, Mouse Genomes, Post-transcriptional Regulatory Network