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BMCBI
2008

Comparative analyses of bidirectional promoters in vertebrates

9 years 7 months ago
Comparative analyses of bidirectional promoters in vertebrates
Background: Orthologous genes with deep phylogenetic histories are likely to retain similar regulatory features. In this report we utilize orthology assignments for pairs of genes co-regulated by bidirectional promoters to map the ancestral history of the promoter regions. Results: Our mapping of bidirectional promoters from humans to fish shows that many such promoters emerged after the divergence of chickens and fish. Furthermore, annotations of promoters in deep phylogenies enable detection of missing data or assembly problems present in higher vertebrates. The functional importance of bidirectional promoters is indicated by selective pressure to maintain the arrangement of genes regulated by the promoter over long evolutionary time spans. Characteristics unique to bidirectional promoters are further elucidated using a technique for unsupervised classification, known as ESPERR. Conclusion: Results of these analyses will aid in our understanding of the evolution of bidirectional pro...
Mary Qu Yang, James Taylor, Laura Elnitski
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where BMCBI
Authors Mary Qu Yang, James Taylor, Laura Elnitski
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