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DAM
2006

Computational complexity of isothermic DNA sequencing by hybridization

10 years 4 months ago
Computational complexity of isothermic DNA sequencing by hybridization
In the paper, the computational complexity of several variants of the problem of isothermic DNA sequencing by hybridization, is analyzed. The isothermic sequencing is a recent method, in which isothermic oligonucleotide libraries are used during the hybridization with an unknown DNA fragment. The variants of the isothermic DNA sequencing problem with errors in the hybridization data, negative ones or positive ones, are proved to be strongly NP-hard. On the other hand, the polynomial time algorithm for the ideal case with no errors is proposed.
Jacek Blazewicz, Marta Kasprzak
Added 11 Dec 2010
Updated 11 Dec 2010
Type Journal
Year 2006
Where DAM
Authors Jacek Blazewicz, Marta Kasprzak
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