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JCNS
2008

A computational study of synaptic mechanisms of partial memory transfer in cerebellar vestibulo-ocular-reflex learning

9 years 29 days ago
A computational study of synaptic mechanisms of partial memory transfer in cerebellar vestibulo-ocular-reflex learning
There is a debate regarding whether motor memory is stored in the cerebellar cortex, or the cerebellar nuclei, or both. Memory may be acquired in the cortex and then be transferred to the cerebellar nuclei. Based on a dynamical system modeling with a minimal set of variables, we theoretically investigated possible mechanisms of memory transfer and consolidation in the context of vestibulo-ocular reflex learning. We tested different plasticity rules for synapses in the cerebellar nuclei and took robustness of behavior against parameter variation as the criterion of plausibility of a model variant. In the most plausible scenarios, mossy-fiber nucleus-neuron synapses or Purkinje-cell nucleus-neuron synapses are plastic on a slow time scale and store permanent memory, whose content is passed from the cerebellar cortex storing transient memory. In these scenarios, synaptic strengths are potentiated when the mossy-fiber afferents to the nuclei are active during a pause in Purkinje-cell activ...
Naoki Masuda, Shun-ichi Amari
Added 26 Jan 2011
Updated 26 Jan 2011
Type Journal
Year 2008
Where JCNS
Authors Naoki Masuda, Shun-ichi Amari
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