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2008

A Cryptographic Approach to Securely Share and Query Genomic Sequences

11 years 9 months ago
A Cryptographic Approach to Securely Share and Query Genomic Sequences
To support large-scale biomedical research projects, organizations need to share person-specific genomic sequences without violating the privacy of their data subjects. In the past, organizations protected subjects' identities by removing identifiers, such as name and social security number; however, recent investigations illustrate that deidentified genomic data can be "reidentified" to named individuals using simple automated methods. In this paper, we present a novel cryptographic framework that enables organizations to support genomic data mining without disclosing the raw genomic sequences. Organizations contribute encrypted genomic sequence records into a centralized repository, where the administrator can perform queries, such as frequency counts, without decrypting the data. We evaluate the efficiency of our framework with existing databases of single nucleotide polymorphism (SNP) sequences and demonstrate that the time needed to complete count queries is feasibl...
Murat Kantarcioglu, Wei Jiang, Ying Liu, Bradley M
Added 29 Dec 2010
Updated 29 Dec 2010
Type Journal
Year 2008
Where TITB
Authors Murat Kantarcioglu, Wei Jiang, Ying Liu, Bradley Malin
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