Sciweavers

Share
NAR
2016

dbSUPER: a database of super-enhancers in mouse and human genome

4 years 3 months ago
dbSUPER: a database of super-enhancers in mouse and human genome
Super-enhancers are the clusters of transcriptional enhancers that can drive cell-type-specific gene expression and also crucial in cell identity. Many disease-associated sequence variations are enriched in super-enhancer regions of disease-relevant cell types. Thus, super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance. However, no centralized resource to integrate all these findings is available yet. We developed dbSUPER (http://bioinfo.au.tsinghua.edu.cn/dbsuper/), the first integrated and interactive database of superenhancers, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease. dbSUPER provides a responsive and user-friendly web interface to facilitate efficient and comprehensive search and browsing. The data can be easily sent to G...
Aziz Khan, Xuegong Zhang
Added 08 Apr 2016
Updated 08 Apr 2016
Type Journal
Year 2016
Where NAR
Authors Aziz Khan, Xuegong Zhang
Comments (0)
books