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RECOMB
2010
Springer

Detecting Highways of Horizontal Gene Transfer

8 years 8 months ago
Detecting Highways of Horizontal Gene Transfer
Abstract. In a horizontal gene transfer (HGT) event a gene is transferred between two species that do not share an ancestor-descendant relationship. Typically, no more than a few genes are horizontally transferred between any two species. However, several studies identified pairs of species between which many different genes were horizontally transferred. Such a pair is said to be linked by a highway of gene sharing. We present a method for inferring such highways. Our method is based on the fact that the evolutionary histories of horizontally transferred genes disagree with the corresponding species phylogeny. Specifically, given a set of gene trees and a trusted rooted species tree, each gene tree is first decomposed into its constituent quartet trees and the quartets that are inconsistent with the species tree are identified. Our method finds a pair of species such that a highway between them explains the largest (normalized) fraction of inconsistent quartets. For a problem on ...
Mukul S. Bansal, J. Peter Gogarten, Ron Shamir
Added 30 Jan 2011
Updated 30 Jan 2011
Type Journal
Year 2010
Where RECOMB
Authors Mukul S. Bansal, J. Peter Gogarten, Ron Shamir
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