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BMCBI
2010

DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules

9 years 2 months ago
DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules
Background: Large microarray datasets have enabled gene regulation to be studied through coexpression analysis. While numerous methods have been developed for identifying differentially expressed genes between two conditions, the field of differential coexpression analysis is still relatively new. More specifically, there is so far no sensitive and untargeted method to identify gene modules (also known as gene sets or clusters) that are differentially coexpressed between two conditions. Here, sensitive and untargeted means that the method should be able to construct de novo modules by grouping genes based on shared, but subtle, differential correlation patterns. Results: We present DiffCoEx, a novel method for identifying correlation pattern changes, which builds on the commonly used Weighted Gene Coexpression Network Analysis (WGCNA) framework for coexpression analysis. We demonstrate its usefulness by identifying biologically relevant, differentially coexpressed modules in a rat can...
Bruno M. Tesson, Rainer Breitling, Ritsert C. Jans
Added 13 Jan 2011
Updated 13 Jan 2011
Type Journal
Year 2010
Where BMCBI
Authors Bruno M. Tesson, Rainer Breitling, Ritsert C. Jansen
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