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BMCBI
2007

Differential analysis for high density tiling microarray data

13 years 3 months ago
Differential analysis for high density tiling microarray data
Background: High density oligonucleotide tiling arrays are an effective and powerful platform for conducting unbiased genome-wide studies. The ab initio probe selection method employed in tiling arrays is unbiased, and thus ensures consistent sampling across coding and non-coding regions of the genome. These arrays are being increasingly used to study the associated processes of transcription, transcription factor binding, chromatin structure and their association. Studies of differential expression and/or regulation provide critical insight into the mechanics of transcription and regulation that occurs during the developmental program of a cell. The time-course experiment, which comprises an in-vivo system and the proposed analyses, is used to determine if annotated and un-annotated portions of genome manifest coordinated differential response to the induced developmental program. Results: We have proposed a novel approach, based on a piece-wise function – to analyze genome-wide di...
Srinka Ghosh, Heather A. Hirsch, Edward A. Sekinge
Added 12 Dec 2010
Updated 12 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Srinka Ghosh, Heather A. Hirsch, Edward A. Sekinger, Philipp Kapranov, Kevin Struhl, Thomas R. Gingeras
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