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BMCBI
2005

Discovery of protein-protein interactions using a combination of linguistic, statistical and graphical information

10 years 2 months ago
Discovery of protein-protein interactions using a combination of linguistic, statistical and graphical information
Background: The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their area of interest. Results: This paper reports a scalable method for the discovery of protein-protein interactions in abstracts, using a combination of text analytics, statistical and graphical analysis, and a set y implemented rules. Applying these techniques to 12,300 abstracts, a precision of 0.61 and a recall of 0.97 were obtained, (f = 0.74) and when allowing for two-hop and three-hop relations discovered by graphical analysis, the precision was 0.74 (f = 0.83). Conclusion: This combination of linguistic and statistical approaches appears to provide the highest precision and recall thus far reported in detecting protein-protein relations using text analytic approaches. Background Scientists in molecular biology find that a significant technique for studying protein function is through the study of protei...
James W. Cooper, Aaron Kershenbaum
Added 15 Dec 2010
Updated 15 Dec 2010
Type Journal
Year 2005
Where BMCBI
Authors James W. Cooper, Aaron Kershenbaum
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