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JCNS
2010

Disentanglement of local field potential sources by independent component analysis

10 years 8 months ago
Disentanglement of local field potential sources by independent component analysis
The spontaneous activity of working neurons yields synaptic currents that mix up in the volume conductor. This activity is picked up by intracerebral recording electrodes as local field potentials (LFPs), but their separation into original informative sources is an unresolved problem. Assuming that synaptic currents have stationary placing we implemented independent component model for blind source separation of LFPs in the hippocampal CA1 region. After suppressing contaminating sources from adjacent regions we obtained three main local LFP generators. The specificity of the information contained in isolated generators is much higher than in raw potentials as revealed by stronger phase-spike correlation with local putative interneurons. The spatial distribution of the population synaptic input corresponding to each isolated generator was disclosed by current-source density analysis of spatial weights. The found generators match with axonal terminal fields from subtypes of local interne...
Valeri A. Makarov, Ioulia Makarova, Oscar Herreras
Added 28 Jan 2011
Updated 28 Jan 2011
Type Journal
Year 2010
Where JCNS
Authors Valeri A. Makarov, Ioulia Makarova, Oscar Herreras
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