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RECOMB
2001
Springer

DNA segmentation as a model selection process

13 years 8 months ago
DNA segmentation as a model selection process
Previous divide-and-conquer segmentation analyses of DNA sequences do not provide a satisfactory stopping criterion for the recursion. This paper proposes that segmentation be considered as a model selection process. Using the tools in model selection, a limit for the stopping criterion on the relaxed end can be determined. The Bayesian information criterion, in particular, provides a much more stringent stopping criterion than what is currently used. Such a stringent criterion can be used to delineate larger DNA domains. A relationship between the stopping criterion and the average domain size is empirically determined, which may aid in the determination of isochore borders.
Wentian Li
Added 30 Jul 2010
Updated 30 Jul 2010
Type Conference
Year 2001
Where RECOMB
Authors Wentian Li
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