A duplication growth model of gene expression networks

Motivation: There has been considerable interest in developing computational techniques for inferring genetic regulatory networks from whole-genome expression profiles. When expression time series data sets are available, dynamic models can, in principle, be used to infer correlative relationships between gene expression levels, which may be causal. However, because of the range of detectable expression levels and the current quality of the data, the predictive nature of such inferred, quantitative models is questionable. Network models derived from simple rate laws offer an intermediate level analysis, going beyond simple statistical analysis, but falling short of a fully quantitative description. This work shows how such network models can be constructed and describes the global properties of the networks derived from such a model. These global properties are statistically robust and provide insights into the design of the underlying network. Results: Several whole-genome expression...

• Type: Journal
• Year: 2002
• Where: BIOINFORMATICS
• Authors: Ashish Bhan, David J. Galas, T. Gregory Dewey
• Keywords: BIOINFORMATICS 2002, Biological Networks, Expression Levels, Whole-genome Expression