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2000

Explanatory Analysis of the Metabolome Using Genetic Programming of Simple, Interpretable Rules

8 years 12 months ago
Explanatory Analysis of the Metabolome Using Genetic Programming of Simple, Interpretable Rules
Genetic programming, in conjunction with advanced analytical instruments, is a novel tool for the investigation of complex biological systems at the whole-tissue level. In this study, samples from tomato fruit grown hydroponically under both high- and low-salt conditions were analysed using Z .Fourier-transform infrared spectroscopy FTIR , with the aim of identifying spectral and biochemical features linked to salinity in the growth environment. FTIR spectra of whole tissue extracts are not amenable to direct visual analysis, so numerical modelling methods were used to generate models Z .capable of classifying the samples based on their spectral characteristics. Genetic programming GP provided models with a better prediction accuracy to the conventional data modelling methods used, whilst being much easier to interpret in terms of the variables used. Examination of the GP-derived models showed that there were a small number of spectral regions that were consistently being used. In part...
Helen E. Johnson, Richard J. Gilbert, Michael K. W
Added 18 Dec 2010
Updated 18 Dec 2010
Type Journal
Year 2000
Where GPEM
Authors Helen E. Johnson, Richard J. Gilbert, Michael K. Winson, Royston Goodacre, Aileen R. Smith, Jem J. Rowland, Michael A. Hall, Douglas B. Kell
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