Extracting transcription factor binding sites from unaligned gene sequences with statistical models

Background: Transcription factor binding sites (TFBSs) are crucial in the regulation of gene transcription. Recently, chromatin immunoprecipitation followed by cDNA microarray hybridization (ChIP-chip array) has been used to identify potential regulatory sequences, but the procedure can only map the probable protein-DNA interaction loci within 1

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Chung-Chin Lu, Wei-Hao Yuan, Te-Ming Chen
• Keywords: BMCBI 2008, CDNA Microarray Hybridization, Chromatin Immunoprecipitation, Transcription Factor