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WABI
2010
Springer

Fast Mapping and Precise Alignment of AB SOLiD Color Reads to Reference DNA

13 years 2 months ago
Fast Mapping and Precise Alignment of AB SOLiD Color Reads to Reference DNA
Abstract. Applied Biosystems’ SOLiD system offers a low-cost alternative to the traditional Sanger method of DNA sequencing. We introduce two main algorithms of mapping SOLiD’s color reads onto a reference genome. The first method performs mapping by adapting a greedy alignment framework. In such an alignment, reads are mapped to approximate genome positions, allowing for a pre-specified bound on sequence difference that combines nucleotide mismatches, gaps, and sequencing errors. The second method for precise alignment relies on a pair hidden Markov model framework, combining a DNA sequence evolution model and sequencing errors (from read quality files).
Miklós Csürös, Szilveszter Juhos,
Added 31 Jan 2011
Updated 31 Jan 2011
Type Journal
Year 2010
Where WABI
Authors Miklós Csürös, Szilveszter Juhos, Attila Bérces
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