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CAIP
2007
Springer

Flexibility Description of the MET Protein Stalk Based on the Use of Non-uniform B-Splines

9 years 6 months ago
Flexibility Description of the MET Protein Stalk Based on the Use of Non-uniform B-Splines
Abstract. The MET protein controls growth, invasion, and metastasis in cancer cells and is thereby of interest to study, for example from a structural point of view. For individual particle imaging by Cryo-Electron Tomography of the MET protein, or other proteins, dedicated image analysis methods are required to extract information in a robust way as the images have low contrast and resolution (with respect to the size of the imaged structure). We present a method to identify the two parts of the MET protein, -propeller and stalk, using a fuzzy framework. Furthermore, we describe how a representation of the MET stalk, denoted stalk curve, can be identified based on the use of non-uniform B-splines. The stalk curve is used to extract relevant geometrical information about the stalk, e.g., to facilitate curvature and length measurements.
Magnus Gedda, Stina Svensson
Added 12 Aug 2010
Updated 12 Aug 2010
Type Conference
Year 2007
Where CAIP
Authors Magnus Gedda, Stina Svensson
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