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2008
IEEE

Flexible image registration for the identification of best fitted protein models in 3D-EM maps

11 years 3 months ago
Flexible image registration for the identification of best fitted protein models in 3D-EM maps
In this work we propose an image registration algorithm to automatically fit protein atomic domain models into medium-resolution three-dimensional electron microscopy reconstructions (3D-EM map). The approach employs a flexible registration algorithm whose optimizer controls the generation of stereo-chemically correct models from a given reference domain belonging to a super-family of proteins. The proposed algorithm generates models automatically in the correct direction until the optimizer converges to the best fitted model. A local gradient optimizer is employed for this task. Mutual Information is used as an alternative to Cross Correlation Coefficient. An additional rigid registration that uses a local gradient optimization is applied between each generated model and the 3D-EM map.
Andrés Santos, Carlos Oscar Sánchez
Added 20 Nov 2009
Updated 20 Nov 2009
Type Conference
Year 2008
Where ISBI
Authors Andrés Santos, Carlos Oscar Sánchez Sorzano, José María Carazo, Julian Atienza-Herrero, Laura Fernandez-de-Manuel, María J. Ledesma-Carbayo
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