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BMCBI
2008

Function2Gene: A gene selection tool to increase the power of genetic association studies by utilizing public databases and expe

9 years 1 months ago
Function2Gene: A gene selection tool to increase the power of genetic association studies by utilizing public databases and expe
Background: Many common disorders have multiple genetic components which convey increased susceptibility. SNPs have been used to identify genetic components which are associated with a disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power. Results: We present a set of programs which implement a novel method for searching for diseaseassociated genes using prior information to select and order genes from publicly available databases by their prior likelihood of association with the disease. These programs were used in a published study of childhood-onset SLE which yielded novel associations with modest sample size. Conclusion: Using prior information to decrease the size of the problem space to an amount commensurate with available samples and resources while maintaining appropriate power enables researchers to increase their likelihood of discovering reproducible associations. Background Many common disorders have genetic componen...
Don L. Armstrong, Chaim O. Jacob, Raphael Zidovetz
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where BMCBI
Authors Don L. Armstrong, Chaim O. Jacob, Raphael Zidovetzki
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