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BMCBI
2008

Functional site prediction selects correct protein models

11 years 5 months ago
Functional site prediction selects correct protein models
Background: The prediction of protein structure can be facilitated by the use of constraints based on a knowledge of functional sites. Without this information it is still possible to predict which residues are likely to be part of a functional site and this information can be used to select model structures from a variety of alternatives that would correspond to a functional protein. Results: Using a large collection of protein-like decoy models, a score was devised that selected those with predicted functional site residues that formed a cluster. When tested on a variety of small // type proteins, including enzymes and non-enzymes, those that corresponded to the native fold were ranked highly. This performance held also for a selection of larger // proteins that played no part in the development of the method. Conclusion: The use of predicted site positions provides a useful filter to discriminate native-like protein models from non-native models. The method can be applied to any co...
Vijayalakshmi Chelliah, William R. Taylor
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where BMCBI
Authors Vijayalakshmi Chelliah, William R. Taylor
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