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2012

FUSE: a system for data-driven multi-level functional summarization of protein interaction networks

8 years 10 months ago
FUSE: a system for data-driven multi-level functional summarization of protein interaction networks
Despite recent progress in high-throughput experimental studies, systems level visualization and analysis of large protein interaction networks (ppi) remains a challenging task, given its scale and high-dimensionality. Specifically, techhat automatically abstract and summarize ppis at multiple resolutions to provide high level views of its functional landscape are still lacking. In this demonstration, we present a novel data-driven and generic system called fuse (Functional Summary Generator) that generates functional maps of a ppi at different levels of organization, from broad process-process level interactions to in-depth complex-complex level interactions. By simultaneously evaluating interaction and annotation data, fuse abstracts higher-order interaction maps by reducing the details of the underlying ppi to form a functional summary graph of interconnected functional clusters. We demonstrate various innovative features of fuse which aid users to visualize these summaries in a ...
Boon-Siew Seah, Sourav S. Bhowmick, Charles Forbes
Added 24 Apr 2012
Updated 24 Apr 2012
Type Journal
Year 2012
Where IHI
Authors Boon-Siew Seah, Sourav S. Bhowmick, Charles Forbes Dewey Jr., Hanry Yu
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