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2008

GemCell: A generic platform for modeling multi-cellular biological systems

8 years 4 months ago
GemCell: A generic platform for modeling multi-cellular biological systems
The mass and complexity of biological information requires computer-aided simulation and analysis to help scientists achieve understanding and guide experimentation. Although living organisms are composed of cells, actual genomic and proteomic data have not yet led to a satisfactory model of working cell in silico. We have set out to devise a user-friendly generic platform, GemCell, for Generic Executable Modeling of Cells, based on whole, functioning cells. Starting with the cell simplifies life, because all cells expresses essentially five generic types of behavior: replication, death, movement (including change of shape and adherence), export (secretion, signaling, etc.) and import (receiving signals, metabolites, phagocytosis, etc.). The details of these behaviors are specified in GemCell for particular kinds of cells as part of a database of biological specifics (the DBS), which specifies the cell properties and functions that depend on the cell's history, state, environment...
Hila Amir-Kroll, Avital Sadot, Irun R. Cohen, Davi
Added 15 Dec 2010
Updated 15 Dec 2010
Type Journal
Year 2008
Where TCS
Authors Hila Amir-Kroll, Avital Sadot, Irun R. Cohen, David Harel
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