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BMCBI
2011

GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models

8 years 9 months ago
GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models
Background: G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and physiological function. GPCR malfunction is responsible for a wide range of diseases including cancer, diabetes and hyperthyroidism and a large proportion of drugs on the market target these receptors. The three dimensional structure of GPCRs is important for elucidating the molecular mechanisms underlying these diseases and for performing structure-based drug design. Although structural data are restricted to only a handful of GPCRs, homology models can be used as a proxy for those receptors not having crystal structures. However, many researchers working on GPCRs are not experienced homology modellers and are therefore unable to benefit from the information that can be gleaned from such three-dimensional models. Here, we present a comprehensive database called the GPCR-SSFE, which provides initial homology ...
Catherine L. Worth, Annika Kreuchwig, Gunnar Klein
Added 24 Aug 2011
Updated 24 Aug 2011
Type Journal
Year 2011
Where BMCBI
Authors Catherine L. Worth, Annika Kreuchwig, Gunnar Kleinau, Gerd Krause
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