A grid-based HIV expert system

10 years 4 months ago
A grid-based HIV expert system
ABSTRACT. Objectives. This paper addresses Grid-based integration and access of distributed data from infectious disease patient databases, literature on in-vitro and in-vivo pharmaceutical data, mutation databases, clinical trials, simulations and medical expert knowledge. Methods. Multivariate analyses combined with rule-based fuzzy logic are applied to the integrated data to provide ranking of patient-specific drugs. In addition, cellular automata-based simulations are used to predict the drug behaviour over time. Access to and integration of data is done through existing Internet servers and emerging Grid-based frameworks like Globus. Data presentation is done by standalone PC based software, Web-access and PDA roaming WAP access. The experiments were carried out on the DAS2, a Dutch Grid testbed. Results. The output of the problem-solving environment (PSE) consists of a prediction of the drug sensitivity of the virus, generated by comparing the viral genotype to a relational data...
Peter M. A. Sloot, Alexander Boukhanovsky, Wilco K
Added 24 Jun 2010
Updated 24 Jun 2010
Type Conference
Year 2005
Authors Peter M. A. Sloot, Alexander Boukhanovsky, Wilco Keulen, Charles A. Boucher
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