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NIPS
2004

A Hidden Markov Model for de Novo Peptide Sequencing

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A Hidden Markov Model for de Novo Peptide Sequencing
De novo Sequencing of peptides is a challenging task in proteome research. While there exist reliable DNA-sequencing methods, the highthroughput de novo sequencing of proteins by mass spectrometry is still an open problem. Current approaches suffer from a lack in precision to detect mass peaks in the spectrograms. In this paper we present a novel method for de novo peptide sequencing based on a hidden Markov model. Experiments effectively demonstrate that this new method significantly outperforms standard approaches in matching quality.
Bernd Fischer, Volker Roth, Joachim M. Buhmann, Jo
Added 31 Oct 2010
Updated 31 Oct 2010
Type Conference
Year 2004
Where NIPS
Authors Bernd Fischer, Volker Roth, Joachim M. Buhmann, Jonas Grossmann, Sacha Baginsky, Wilhelm Gruissem, Franz F. Roos, Peter Widmayer
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