Sciweavers

Share
NN
2006
Springer

Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making

10 years 4 months ago
Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making
The basal ganglia (BG) coordinate decision making processes by facilitating adaptive frontal motor commands while suppressing others. In previous work, neural network simulations accounted for response selection deficits associated with BG dopamine depletion in Parkinson's disease. Novel predictions from this model have been subsequently confirmed in Parkinson patients and in healthy participants under pharmacological challenge. Nevertheless, one clear limitation of that model is in its omission of the subthalamic nucleus (STN), a key BG structure that participates in both motor and cognitive processes. The present model incorporates the STN and shows that by modulating when a response is executed, the STN reduces premature responding and therefore has substantial effects on which response is ultimately selected, particularly when there are multiple competing responses. Increased cortical response conflict leads to dynamic adjustments in response thresholds via cortico-subthalami...
Michael J. Frank
Added 14 Dec 2010
Updated 14 Dec 2010
Type Journal
Year 2006
Where NN
Authors Michael J. Frank
Comments (0)
books