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BMCBI
2010

Identifying common prognostic factors in genomic cancer studies: A novel index for censored outcomes

11 years 5 months ago
Identifying common prognostic factors in genomic cancer studies: A novel index for censored outcomes
Background: With the growing number of public repositories for high-throughput genomic data, it is of great interest to combine the results produced by independent research groups. Such a combination allows the identification of common genomic factors across multiple cancer types and provides new insights into the disease process. In the framework of the proportional hazards model, classical procedures, which consist of ranking genes according to the estimated hazard ratio or the p-value obtained from a test statistic of no association between survival and gene expression level, are not suitable for gene selection across multiple genomic datasets with different sample sizes. We propose a novel index for identifying genes with a common effect across heterogeneous genomic studies designed to remain stable whatever the sample size and which has a straightforward interpretation in terms of the percentage of separability between patients according to their survival times and gene expressio...
Sigrid Rouam, Thierry Moreau, Philippe Broët
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2010
Where BMCBI
Authors Sigrid Rouam, Thierry Moreau, Philippe Broët
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