Imaging of spatiotemporal coincident states by DC optical tomography

The utility of optical tomography as a practical imaging modality has, thus far, been limited by its intrinsically low spatial resolution and quantitative accuracy. Recently, we have argued that a broad range of physiological phenomena might be accurately studied by adopting this technology to investigate dynamic states (Schmitz et al., 2000; Barbour et al., 2000; Graber et al., 2000; Barbour et al., 2001; and Barbour et al., 1999). One such phenomenon holding considerable significance is the dynamics of the vasculature, which has been well characterized as being both spatially and temporally heterogeneous. In this paper, we have modeled such heterogeneity in the limiting case of spatiotemporal coincident behavior involving optical contrast features, in an effort to define the expected limits with which dynamic states can be characterized using two newly described reconstruction methods that evaluate normalized detector data: the normalized difference method (NDM) and the normalized co...

• Type: Journal
• Year: 2002
• Where: TMI
• Authors: Harry L. Graber, Yaling Pei, Randall L. Barbour
• Keywords: Barbour Et, Dynamic States, Spatial Resolution, TMI 2002