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2008
IEEE

Inferring the Function of Genes from Synthetic Lethal Mutations

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Inferring the Function of Genes from Synthetic Lethal Mutations
—Techniques for detecting synthetic lethal mutations in double gene deletion experiments are emerging as powerful tool for analysing genes in parallel or overlapping pathways with a shared function. This paper introduces a logic-based approach that uses synthetic lethal mutations for mapping genes of unknown function to enzymes in a known metabolic network. We show how such mappings can be automatically computed by a logical learning system called eXtended Hybrid Abductive Inductive Learning (XHAIL).
Oliver Ray, Christopher H. Bryant
Added 29 May 2010
Updated 29 May 2010
Type Conference
Year 2008
Where CISIS
Authors Oliver Ray, Christopher H. Bryant
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