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IJON
2007

Inhibitory conductance dynamics in cortical neurons during activated states

9 years 11 months ago
Inhibitory conductance dynamics in cortical neurons during activated states
During activated states in vivo, neocortical neurons are subject to intense synaptic activity and high-amplitude membrane potential ðVmÞ fluctuations. These ‘‘high-conductance’’ states may strongly affect the integrative properties of cortical neurons. We investigated the responsiveness of cortical neurons during different states using a combination of computational models and in vitro experiments (dynamic-clamp) in the visual cortex of adult guinea pigs. Spike responses were monitored following stochastic conductance injection in both experiments and models. We found that cortical neurons can operate in a continuum between two different modes: during states with equal excitatory and inhibitory conductances, the firing is mostly correlated with an increase in excitatory conductance, which is a rather classic scenario. In contrast, during states dominated by inhibition, the firing is mostly related to a decrease in inhibitory conductances (dis-inhibition). This model predi...
Martin Pospischil, Zuzanna Piwkowska, Michelle Rud
Added 15 Dec 2010
Updated 15 Dec 2010
Type Journal
Year 2007
Where IJON
Authors Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal, Alain Destexhe
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