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IJON
2000

A large-scale model of the cerebellar cortex using PGENESIS

13 years 3 months ago
A large-scale model of the cerebellar cortex using PGENESIS
In an investigation into the transformation of mossy ber input to Purkinje cell output in the cerebellar cortex, we have developed a network model including a sophisticated compartmental model of the Purkinje cell. Analysis and simulations demonstrated the need to include a large number of parallel bers (244,000) to obtain realistic Purkinje cell ring patterns for random mossy ber input. Using smaller numbers of parallel ber inputs resulted in unrealistic Purkinje cell spiking characterized by spontaneous dendritic calcium spikes. Because the scale required is beyond workstation capabilites, we used a 128-processor Cray T3E running PGENESIS. This size network could producerealistic spikingpatterns provided the stellate cell inhibition was tuned carefully. Key words: Large scale modelling PGENESIS Cerebellum
F. W. Howell, Jonas Dyhrfjeld-Johnsen, Reinoud Mae
Added 18 Dec 2010
Updated 18 Dec 2010
Type Journal
Year 2000
Where IJON
Authors F. W. Howell, Jonas Dyhrfjeld-Johnsen, Reinoud Maex, Nigel H. Goddard, Erik De Schutter
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