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ISBI
2007
IEEE

Localizing Amygdala Structure Differences in Late-life Depression

9 years 4 months ago
Localizing Amygdala Structure Differences in Late-life Depression
The amygdala is critical for processing emotional information and plays an important role in late-life depression (LLD). Volumetric studies of the amygdala have been inconclusive with reports of increased, decreased, and no volume changes. This study investigates amygdala shape morphemetry to test the hypothesis that if structural changes are specific to certain nuclei, then shape changes may be apparent even when overall volume changes are inconsistent. We have developed a method of shape morphometry based on the work of [1] to localize regions of structural differences. The method relies on generating surface meshes for segmented amygdalae, calculating distances from surface points to the medial manifold, and comparing the distance measures at corresponding surface points between groups. Resulting statistical maps revealed significant structural differences in multiple regions of both amygdalae. Shape morphometry can potentially relate local structure variation to underlying neuro...
Robert J. Tamburo, Greg J. Siegle, George D. Stett
Added 03 Jun 2010
Updated 03 Jun 2010
Type Conference
Year 2007
Where ISBI
Authors Robert J. Tamburo, Greg J. Siegle, George D. Stetten, Aaron Cois, Ken J. Rockot, John M. Galeotti, Charles F. Reynolds III, Howard Aizenstein
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