MCM-test: a fuzzy-set-theory-based approach to differential analysis of gene pathways

Background: Gene pathway can be defined as a group of genes that interact with each other to perform some biological processes. Along with the efforts to identify the individual genes that play vital roles in a particular disease, there is a growing interest in identifying the roles of gene pathways in such diseases. Results: This paper proposes an innovative fuzzy-set-theory-based approach, Multi-dimensional Cluster Misclassification test (MCM-test), to measure the significance of gene pathways in a particular disease. Experiments have been conducted on both synthetic data and real world data. Results on published diabetes gene expression dataset and a list of predefined pathways from KEGG identified OXPHOS pathway involved in oxidative phosphorylation in mitochondria and other mitochondrial related pathways to be deregulated in diabetes patients. Our results support the previously supported notion that mitochondrial dysfunction is an important event in insulin resistance and type-2 ...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Lily R. Liang, Vinay Mandal, Yi Lu, Deepak Kumar
• Keywords: BMCBI 2008, Gene Expression, Gene Pathways, Particular Disease