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2006
IEEE

A method to improve structural modeling based on conserved domain clusters

10 years 9 months ago
A method to improve structural modeling based on conserved domain clusters
—Homology modeling requires an accurate alignment between a query sequence and its homologs with known three-dimensional (3D) information. Current structural modeling techniques largely use entire protein chains as templates, which are selected based only on their sequence alignments with the queries. Protein can be largely described as combinations of conserved domains, and already more than two-third of the known protein domains can be found in the Protein Data Bank (PDB). We presented a method to improve structural modeling based on conserved domain clusters. First, we searched and mapped all the InterPro domains in the entire PDB, partitioned and clustered homologous domains into the domain-based template library. For each of the resulting clusters created, a multiple structural alignment was generated based only on the 3D coordinates of all the residues involved. Then we used the structural alignments as anchors to increase the alignment accuracy between a query and its template...
Fa Zhang, Lin Xu, Bo Yuan
Added 12 Jun 2010
Updated 12 Jun 2010
Type Conference
Year 2006
Where IPPS
Authors Fa Zhang, Lin Xu, Bo Yuan
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