Sciweavers

Share
ICARIS
2007
Springer

Modeling Migration, Compartmentalization and Exit of Naive T Cells in Lymph Nodes Without Chemotaxis

9 years 4 months ago
Modeling Migration, Compartmentalization and Exit of Naive T Cells in Lymph Nodes Without Chemotaxis
The migration of lymphocytes through secondary lymphoid organs was believed to be mainly controlled by chemokine gradients. This theory has recently been called into question since naive lymphocytes observed in vivo by two-photon microscopy show no evidence of directed migration. We have constructed a simple mathematical model of naive T cell migration in lymph nodes that is solely based on local mechanisms. The model was validated against findings from histological analysis and experimentally determined lymphocyte recirculation kinetics. Our results suggest that T cell compartmentalization in lymph nodes can be explained without long-range chemokine gradients. However, the T cell residence time predicted by our model is significantly lower than observed in vivo, indicating the existence of a mechanism which alters the T cell random walk over time.
Johannes Textor, Jürgen Westermann
Added 08 Jun 2010
Updated 08 Jun 2010
Type Conference
Year 2007
Where ICARIS
Authors Johannes Textor, Jürgen Westermann
Comments (0)
books