Modelling the correlation between the activities of adjacent genes in drosophila

Background: Correlation between the expression levels of genes which are located close to each other on the genome has been found in various organisms, including yeast, drosophila and humans. Since such a correlation could be explained by several biochemical, evolutionary, genetic and technological factors, there is a need for statistical models that correspond to specific biological models for the correlation structure. Results: We modelled the pairwise correlation between the expressions of the genes in a Drosophila microarray experiment as a normal mixture under Fisher's z-transform, and fitted the model to the correlations of expressions of adjacent as well as non-adjacent genes. We also analyzed simulated data for comparison. The model provided a good fit to the data. Further, correlation between the activities of two genes could, in most cases, be attributed to either of two factors: the two genes both being active in the same age group (adult or embryo), or the two genes b...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Helene H. Thygesen, Aeilko H. Zwinderman
• Keywords: Adjacent Genes, BMCBI 2005, Expression Levels, Non-adjacent Genes