Modelling the early steps of transduction in insect olfactory receptor neurons

Olfactory transduction is a multistep process whose basic function is to convert a low energy reaction, the odorant-receptor interaction that may involve a single odorant molecule, into a whole cell electrical response, the receptor potential, which triggers the firing of one or more action potentials. Although much effort has been devoted to the experimental analysis of transduction in olfactory receptor neurons (ORNS), especially in the favorable moth sex-pheromone receptor neuron, its modelling is less advanced. The model we investigated, which takes into account the translocation of pheromone molecules from air to the extracellular space, their deactivation and their interaction with receptors, focuses on the membrane cascade. It involves the interaction of receptors, G-proteins and effector enzymes, whose reaction rates are limited by lateral diffusion in the membrane. The evolutions in time of these species in response to single pulse stimulation of various intensities were com...

• Type: Journal
• Year: 2007
• Where: BIOSYSTEMS
• Authors: Jean-Pierre Rospars, Philippe Lucas, Mathieu Coppey
• Keywords: BIOSYSTEMS 2007, Electrical Response, Olfactory Receptor Neurons, Receptor Neuron