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LION
2009
Springer

Neural Network Pairwise Interaction Fields for Protein Model Quality Assessment

9 years 3 months ago
Neural Network Pairwise Interaction Fields for Protein Model Quality Assessment
We present a new knowledge-based Model Quality Assessment Program (MQAP) at the residue level which evaluates single protein structure models. We use a tree representation of the Cα trace to train a novel Neural Network Pairwise Interaction Field (NN-PIF) to predict the global quality of a model. We also attempt to extract local quality from global quality. The model allows fast evaluation of multiple different structure models for a single sequence. In our tests on a large set of structures, our model outperforms most other methods based on different and more complex protein structure representations in both local and global quality prediction. The method is available upon request from the authors. Method-specific rankers may also built by the authors upon request.
Alberto J. M. Martin, Alessandro Vullo, Gianluca P
Added 27 May 2010
Updated 27 May 2010
Type Conference
Year 2009
Where LION
Authors Alberto J. M. Martin, Alessandro Vullo, Gianluca Pollastri
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