A new look at state-space models for neural data

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A new look at state-space models for neural data
State space methods have proven indispensable in neural data analysis. However, common methods for performing inference in state-space models with non-Gaussian observations rely on certain approximations which are not always accurate. Here we review direct optimization methods that avoid these approximations, but that nonetheless retain the computational efficiency of the approximate methods. We discuss a variety of examples, applying these direct optimization techniques to problems in spike train smoothing, stimulus decoding, parameter estimation, and inference of synaptic properties. Along the way, we point out connections to some related standard statistical methods, including spline smoothing and isotonic regression. Finally, we note that the computational methods reviewed here do not in fact depend on the state-space setting at all; instead, the key property we are exploiting involves the bandedness of certain matrices. We close by discussing some applications of this more genera...
Liam Paninski, Yashar Ahmadian, Daniel Gil Ferreir
Added 28 Jan 2011
Updated 28 Jan 2011
Type Journal
Year 2010
Where JCNS
Authors Liam Paninski, Yashar Ahmadian, Daniel Gil Ferreira, Shinsuke Koyama, Kamiar Rahnama Rad, Michael Vidne, Joshua T. Vogelstein, Wei Wu
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