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GECCO
2007
Springer

A novel ab-initio genetic-based approach for protein folding prediction

9 years 5 months ago
A novel ab-initio genetic-based approach for protein folding prediction
In this paper, a model based on genetic algorithms for protein folding prediction is proposed. The most important features of the proposed approach are: i) Heuristic secondary structure information is used in the initialization of the genetic algorithm; ii) An enhanced 3D spatial representation called cube-octahedron is used, also, an expansion technique is proposed in order to reduce the computational complexity and spatial constraints; iii) Data preprocessing of geometric features to characterize the cubeoctahedron using twelve basic vectors to define the nodes. Additionally, biological information (torsion angles, bond angles and secondary structure conformations) was pre-processed through an analysis of all possible combinations of the basic vectors which satisfy the biological constrains defined by the spatial representation; and iv) Hashing techniques were used to improve the computational efficiency. The pre-processed information was stored in hash tables, which are intensively...
Sergio Raul Duarte Torres, David Camilo Becerra Ro
Added 07 Jun 2010
Updated 07 Jun 2010
Type Conference
Year 2007
Where GECCO
Authors Sergio Raul Duarte Torres, David Camilo Becerra Romero, Luis Fernando Niño Vasquez, Yoan José Pinzón Ardila
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