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BMCBI
2011

A novel approach to the clustering of microarray data via nonparametric density estimation

9 years 27 days ago
A novel approach to the clustering of microarray data via nonparametric density estimation
Background: Cluster analysis is a crucial tool in several biological and medical studies dealing with microarray data. Such studies pose challenging statistical problems due to dimensionality issues, since the number of variables can be much higher than the number of observations. Results: Here, we present a general framework to deal with the clustering of microarray data, based on a three-step procedure: (i) gene filtering; (ii) dimensionality reduction; (iii) clustering of observations in the reduced space. Via a nonparametric model-based clustering approach we obtain promising results both in simulated and real data. Conclusions: The proposed algorithm is a simple and effective tool for the clustering of microarray data, in an unsupervised setting. Background The analysis of gene expression microarray data using clustering techniques plays an important role, for instance, in the discovery, validation, and understanding of various classes and subclasses of cancer [1]. There are two ...
Riccardo De Bin, Davide Risso
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2011
Where BMCBI
Authors Riccardo De Bin, Davide Risso
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