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IJDMB
2010

On a novel coalescent model for genome-wide evolution of Copy Number Variations

9 years 27 days ago
On a novel coalescent model for genome-wide evolution of Copy Number Variations
: Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here, we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model is hoped to lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes.
Antonina Mitrofanova, Bhubaneswar (Bud) Mishra
Added 27 Jan 2011
Updated 27 Jan 2011
Type Journal
Year 2010
Where IJDMB
Authors Antonina Mitrofanova, Bhubaneswar (Bud) Mishra
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